MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.

نویسندگان

  • Yi Guan
  • Hailan Yao
  • Zhihong Zheng
  • Guangrong Qiu
  • Kailai Sun
چکیده

Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal formation. This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene, BCL3. Furthermore, expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development.

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عنوان ژورنال:
  • International journal of cancer

دوره 128 10  شماره 

صفحات  -

تاریخ انتشار 2011